Research Articles

Complete list of published work:   https://www.ncbi.nlm.nih.gov/myncbi/linnaea.ostroff.1/bibliography/public/

Perez-Garza J, Orea J, Deane Z, Raimondi G, Tripp R, Charles I, Ostroff L. (BioRxiv) Ultraplex microscopy: versatile highly-multiplexed molecular labeling and imaging across scale and resolution. doi: 10.1101/2024.08.17.605585

Raimondi G, Eng A, Kenny MP, Britting MA, Ostroff LE. (2024) Track-by-Day: A standardized approach to estrous cycle monitoring in biobehavioral research. Behav Brain Res. 461:114860. doi: 10.1016/j.bbr.2024.114860.

Perez-Garza J, Parrish-Mulliken E, Deane Z, Ostroff LE. (2023) Rehydration of freeze substituted brain tissue for pre-embedding immunoelectron microscopy. Microscopy and Microanalysis 29(5):1694-1704. doi: 10.1093/micmic/ozad077

Hamzehei S, Bai J, Raimondi R, Tripp R, Ostroff L, Nabavi S. (2023) 3D Biological/biomedical image registration with enhanced feature extraction and outlier detection. Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. doi: 10.1145/3584371.3612965.

Perez-Garza J, Orea J, Ostroff LE. (2023) Click chemistry for visualization of newly synthesized RNA and antibody labeling on ultrathin tissue sections. Microscopy and Microanalysis 29(29 Suppl 1):1075-1076. doi: 10.1093/micmic/ozad067.552

Raimondi GM, Tripp R, Ostroff LE. (2023) The Track-by-Day Method for Monitoring the Rodent Estrous Cycle. Curr Protoc. 3(4):e747

Wolcott NS, Sit KK, Raimondi G, Hodges T, Shansky RM, Galea LAM, Ostroff LE, Goard MJ. (2022) Automated classification of estrous stage in rodents using deep learning. Sci Rep 12, 17685

Ostroff LE and Cain CK (2022) Persistent upregulation of polyribosomes at synapses during long-term memory, reconsolidation, and extinction of associative memory. Learning and Memory 29:191-202

Gindina, S, Botsford, B, Cowansage, KK, LeDoux, JE, Klann, E, and Hoeffer, CA, and Ostroff, LE (2021) Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation. J Comp Neurol 529:3112-3126.

Ostroff, LE, Santini, E, Sears, R, Deane, Z, Kanadia, R, LeDoux, JE, Lhakhang, T, Tsirigos, A, Heguy, A, and Klann, E (2019)  Axon TRAP reveals learning-induced alterations in cortical axonal mRNAs in the lateral amgydala. eLife 8:e51607.

Ostroff, LE, Watson, DJ, Cao, G, Parker, PH, Smith, H, and Harris, KM (2018) Shifting patterns of polyribosome accumulation at synapses over the course of hippocampal long-term potentiation.  Hippocampus 28:416-430.  

Ostroff, LE, Botsford, B, Gindina, S, Cowansage, KK, LeDoux, JE, Klann, E, and Hoeffer, CA (2017)  Accumulation of polyribosomes in dendritic spine heads, but not bases and necks, during memory consolidation depends on cap-dependent translation initiation. J Neurosci 37:1862-72.

Smith HL, Bourne, JN, Cao, G, Chirillo, MA, Ostroff, LE, Watson, DJ, and Harris, KM (2016) Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP.  eLife 5. pii: e15275.

Watson, DJ*, Ostroff, LE*, Cao, G, Parker, PH, and Harris, KM (2016) LTP enhances synaptogenesis in the developing hippocampus. Hippocampus 26:560-76. *credited equally

Ostroff, LE, Manzur, M, Cain, CK, and LeDoux, JE (2014) Synapses lacking astrocyte appear in the amygdala during consolidation of Pavlovian threat conditioning. J Comp Neurol 522:2152-63. *Corresponding author

De Rubeis, S, Pasciuto, E, Li, KW, Fernández, E, Di Marino, D, Buzzi, A, Ostroff, LE, Klann, E, Zwartkruis, FJ, Komiyama, NH, Grant, SG, Poujol, C, Choquet, D, Achsel, T, Posthuma, D, Smit, AB, and Bagni, C (2013) CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation. Neuron 79:1169-82.

Ostroff, LE, Cain, CK, Jindal, N, Dar, N, and LeDoux, JE (2012) Stability of presynaptic boutons and changes in synaptic vesicle pools in the rat amygdala with fear learning. J Comp Neurol 520: 295-314.

Ostroff, LE, Cain, CK, Bedont, J, Monfils, M, and LeDoux, JE (2010) Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala. PNAS 107: 9418-23.

Park, M, Salgado, JM, Ostroff, L, Helton, TD, Robinson, CG, Harris, KM, and Ehlers, MD (2006) Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron 52:817-830

Harris, KM, Perry, E, Bourne, J, Feinberg, M, Ostroff, L, and Hurlburt, J (2006) Uniform serial sectioning for transmission electron microscopy. J Neurosci 26:12101-3.

Ostroff, LE, Fiala, JC, Allwardt, B, and Harris, KM (2002) Polyribosomes redistribute from dendritic shafts into spines with enlarged synapses during LTP in developing rat hippocampal slices. Neuron 35:535-45.

Reviews and commentary

Ostroff, L. and Zeng, H. (2015) Electron microscopy at scale.  Cell 162:474-475.

Christianson, J.P., Fernando, A.B., Kazama, A.M., Jovanovic, T., Ostroff, L.E., and Sangha, S.  (2012) Inhibition of Fear by Learned Safety Signals: A Mini-Symposium Review.  J Neurosci 32(41):14118-24.

Johansen, J. P., Cain, C.K., Ostroff, L.E., and LeDoux, J.E.  (2011)  Molecular mechanisms of fear learning and memory.  Cell 147: 509-524.

Ostroff, L. (2012)  Fungal Fruiting Bodies and Fanatics. Science 335:1574-1575.

Ostroff, L. (2011)  DNA Dollars.  Nature 478:456.

Ostroff, L. (2011)  Recalling the future.  Nature 474:34.

Ostroff, L. (2011) A gallery of our mental machinery.  Science 21:285-286.

Uchida, T., Fanghaenel, J., Uchida, C., and Ostroff, L. (2005).  Prolyl isomerase pin1 protecting against ageing diseases.  Tanpakushitsu Kakusan Koso. 50:1413-1419.

Harris, K.M., Fiala, J.C., and Ostroff, L. (2003) Structural changes at dendritic spine synapses during long-term potentiation; Philos Trans R Soc Lond B Biol Sci 358:745-748.